Unintentional weight loss. Proper weight is very necessary for good health and if the weight loss is unintentional, it may be dangerous for the health. Do you want to know of the primary reasons of unintentional weight loss? One of the main reasons of sudden or unintentional weight loss is diabetes. Both Type 1 and Type 2 diabetes results in rapid weight loss, which affects the health adversely. Yes, depression also results in sudden weight loss. One of the major symptoms of depression is drastic weight loss. Stress and weight loss is interrelated to each other. This disease is also responsible for the unexpected weight loss. Cigarette has some harmful substances that have a very affect on health and results in the loss of the weight as well. If you are suffering from nausea then loss of weight is very common and obvious.
Show All Outcome Measures. Show Outcome Measure 1. Percentage Change in Body Weight From Baseline at Week 7 and Week 9 [ Time Frame: Baseline, Week 7 and Week 9 ] Show Outcome Measure 2. Show Outcome Measure 3. Show Outcome Measure 4. Show Outcome Measure 5. Show Outcome Measure 6. Percentage Change From Baseline of Physical Activity Levels (Using the Activ PAL™ Device) Number of Steps Taken Compared to Placebo at Week 4 and 7 [ Time Frame: Baseline, Week 4 and Week 7 ] Show Outcome Measure 7. Percentage Change From Baseline of Physical Activity Levels (Using the Activ PAL™ Device) Time Sedentary Taken Compared to Placebo at Week 4 and 7 [ Time Frame: Baseline, Week 4 and Week 7 ] Show Outcome Measure 8. Percentage Change From Baseline of Physical Activity Levels (Using the Activ PAL™ Device) Time Standing Compared to Placebo at Week 4 and 7 [ Time Frame: Baseline, Week 4 and Week 7 ] Show Outcome Measure 9. Percentage Change From Baseline of Physical Activity Levels (Using the Activ PAL™ Device) Time Stepping Compared to Placebo at Week 4 and 7 [ Time Frame: Baseline, Week 4 and Week 7 ]
Lee Moffitt Cancer Center and Research Institute, Tampa, Florida. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612-9497. Malnutrition from anorexia and reduced nutrient intake is common in patients with cancer. However, other patients may present with cancer cachexia, a wasting syndrome characterized by weight loss, anorexia, early satiety, progressive debilitation, and malnutrition that results in a greater risk of organ dysfunction and death. Because a single cause for these metabolic abnormalities has not been identified, several approaches to treatment of cancer cachexia have been reported. A variety of agents have been studied for their positive effects on appetite, including progestational agents, glucocorticoids, cannabinoids, cyproheptadine, olanzapine, and mirtazapine. Other agents have been investigated for their anti-inflammatory properties, including thalidomide, pentoxyphylline, melatonin, and ω-3 fatty acids. The decision to treat symptoms of cancer cachexia should be based on the patient's desires and current medical condition. Choice of the most appropriate agent to treat unintentional weight loss in patients with cancer should include consideration of effects on appetite, weight, quality of life, and risk of adverse effects according to current evidence-based medicine, and cost and availability of the agent.
Unintentional Weight Loss as the Sole Indication for Colonoscopy is Rarely Associated with Colorectal Cancer. One hundred thirty-six (2.1%) of these had unintentional weight loss; for 32 patients (0.4%), unintentional weight loss was the only indication for the procedure. CRC was diagnosed in 116 patients (1.8%), but CRC was not detected in any patients for whom unintentional weight loss as the only indication for colonoscopy. Conclusion: Based on our prospective case study, unintentional weight loss alone was not associated with CRC. Weight loss is used as an indication for colonoscopy. 5 In this study we examined the association between unintentional weight loss as a sole indication for colonoscopy and the risk for CRC. To examine the relationship of weight loss, age, and sex with CRC, multiple logistic regression was used to calculate an estimate of the odds ratio for each factor. Out of all colonoscopies, 136 (2.1%) had unintentional weight loss as an indication, and only 32 patients (0.4%) had weight loss as the sole indication for the procedure. Of the 136 patients with unintentional weight loss as an indication for colonoscopy, only 5 (0.07%) were diagnosed with CRC, each of whom had unintentional weight loss and an additional indication for colonoscopy (eg, gastrointestinal bleeding, anemia, or abdominal pain). The odds ratio for detecting CRC with weight loss was 1.9 (95% CI, 0.8–4.8; see Table 1 ). The results of this study demonstrate that weight loss as a sole indication for performing colonoscopy may not be sufficient. Our findings suggest that unintentional weight loss as the only indication for colonoscopy may not be associated with CRC.
Clinical Study of BYM 338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or the Pancreas. A safety & efficacy clinical study of the investigational medicinal product BYM 338 for the treatment of unintentional weight loss in patients with cancer of the lung or the pancreas. Percentage Change From Baseline of Thigh Muscle Volume (TMV) by MRI Scan at Week 8 [ Time Frame: Baseline, week 8 ] [ Designated as safety issue: No ] Percentage Change in Body Weight From Baseline at Week 7 and Week 9 [ Time Frame: Baseline, Week 7 and Week 9 ] [ Designated as safety issue: No ] Percentage Change in body weight from baseline in killograms (kg) at week 7 and week 9. Maximum Observed Serum Concentration (Cmax) [ Time Frame: 0, 1, 2, 3, 4, 6, 8, 12, 24, 48, 72, 96 hours post-dose on Day 1 and Week 8 ] [ Designated as safety issue: No ] Time to Reach the Maximum Concentration After Drug Administration (Tmax) [ Time Frame: 0, 1, 2, 3, 4, 6, 8, 12, 24, 48, 72, 96 hours post-dose on Day 1 and Week 8 ] [ Designated as safety issue: No ] Percentage Change From Baseline in Total Lean Body Mass (LBM) by Dual-Energy X-ray Absorptiometery (DXA) Compared to Placebo: at Week 8 [ Time Frame: Baseline, Week 8 ] [ Designated as safety issue: No ] Percentage Change From Baseline of Bone Mineral Density (BMD) by Dual-Energy X-ray Absorptiometery (DXA) Compared to Placebo at Week 8 [ Time Frame: Baseline, Week 8 ] [ Designated as safety issue: No ] Percentage Change From Baseline of Physical Activity Levels (Using the Activ PAL™ Device) Number of Steps Taken Compared to Placebo at Week 4 and 7 [ Time Frame: Baseline, Week 4 and Week 7 ] [ Designated as safety issue: No ] Each patient was required to wear the Activ Pal™ for a span of 6 days at Week 4 and Week 7 for patient home activity recording. Percentage Change From Baseline of Physical Activity Levels (Using the Activ PAL™ Device) Time Sedentary Taken Compared to Placebo at Week 4 and 7 [ Time Frame: Baseline, Week 4 and Week 7 ] [ Designated as safety issue: No ] Percentage Change From Baseline of Physical Activity Levels (Using the Activ PAL™ Device) Time Standing Compared to Placebo at Week 4 and 7 [ Time Frame: Baseline, Week 4 and Week 7 ] [ Designated as safety issue: No ] Percentage Change From Baseline of Physical Activity Levels (Using the Activ PAL™ Device) Time Stepping Compared to Placebo at Week 4 and 7 [ Time Frame: Baseline, Week 4 and Week 7 ] [ Designated as safety issue: No ]
Effect of dietary supplements and physical exercise on sensory perception, appetite, dietary intake and body weight in frail elderly subjects. J Amer Geriatr Soc 1992;40:155-62. J Amer Geriatr Soc 2003;51:85-90. J Amer Geriatr Soc 1995;43:835-6. J Amer Geriatr Soc 2000;48:485-92. Evaluating and treating unintentional weight loss in the elderly. J Amer Geriatr Soc 1994;42:1100-2. J Amer Geriatr Soc 1998;46:1378-86. J Amer Geriatr Soc 2001;49:1309-18. The effects of improved oral hygiene on taste perception and nutrition of the elderly. Effect of flavor enhancement of foods for the elderly on nutritional status: food intake, biochemical indices, and anthropometric measures. Flavor enhancement of food improves dietary intake and nutritional status of elderly nursing home residents. Evaluation of the dietary intake of homebound elderly and the feasibility of dietary supplementation.
Weight loss is a common problem in patients with pancreatic cancer. The weight loss can be associated with treatment or the cancer itself. Unexplained weight loss may be an early symptom of pancreatic cancer and can occur without any pain or apparent change in digestion. In addition, please note that any personal information you provide to Pan CAN’s associates during telephone and/or email communications may be stored and used to help Pan CAN achieve its mission of assisting patients with, and finding cures and treatments for, pancreatic cancer. Information also may be provided in aggregate or limited formats to third parties to guide future pancreatic cancer research and treatment efforts.
Weight loss.       Poor nutrient utilization can lead to weight loss, and can be caused by fistulae in the gastrointestinal tract, diarrhea, drug-nutrient interaction, enzyme depletion and muscle atrophy. Unintentional weight loss can be the characteristic leading to diagnosis of diseases such as cancer  and type 1 diabetes .  Around 25% experience moderate to severe weight loss, and most others have some weight loss. People with HIV often experience weight loss, and it is associated with poorer outcomes. Intentional weight loss is the loss of total body mass as a result of efforts to improve fitness and health, or to change appearance through slimming. Weight loss in individuals who are overweight or obese can reduce health risks,  increase fitness,  and may delay the onset of diabetes . Weight loss occurs when the body is expending more energy in work and metabolism than it is absorbing from food or other nutrients. The healthiest weight loss regimen, therefore, is one that consists of a balanced diet and moderate physical activity.[ citation needed ] In order for weight loss to be permanent, changes in diet and lifestyle must be permanent as well.
Evaluating and Treating Unintentional Weight Loss in the Elderly. Elderly patients with unintentional weight loss are at higher risk for infection, depression and death. Food and Drug Administration has labeled no appetite stimulants for the treatment of weight loss in the elderly. Unintentional weight loss in the elderly patient can be difficult to evaluate. Selected Medications Associated with Unintentional Weight Loss in the Elderly. The use of formal screening instruments for depression, such as the Geriatric Depression Scale, 25 may be necessary in the elderly patient with unintentional weight loss. However, none are specifically indicated for the treatment of weight loss in elderly patients, and few have been studied in this population. Food and Drug Administration has not labeled any of these drugs for use in elderly patients with weight loss. Although medications may help promote appetite and weight gain in an elderly patient with unintentional weight loss, drugs should not be considered first-line treatment. Low body weight and weight loss in the aged. Unexplained weight loss in the ambulatory elderly. Diagnosis and management of weight loss in the elderly.
Treating and managing these symptoms can help you feel better and allow you to continue with more of your usual activities. These substances can lead to weight loss, muscle loss, and a decrease in appetite. They can also lead to side effects such as nausea, vomiting, and mouth sores, which can affect your ability to eat normally, further contributing to weight and muscle loss. Fatigue is also a factor, since the decreases in exercise and other physical activities that happen when you’re not feeling well can also contribute to muscle loss. How are weight changes and muscle loss treated? These drugs can increase appetite for some people and may help to prevent weight and muscle loss, but they do not build up lost muscle tissue. What can I do to help maintain my weight and build strength? You can also try some upper body exercises while sitting in a chair – moving your arms up and down and front to back can help maintain flexibility. Making a fist and lifting your arms up and down in front of you can increase strength. Note the type of exercises or other physical activities you do and how they affect your mood and energy level. Nutritionists and physical or occupational therapists can advise you on other ways to maintain your weight and build strength as you cope with cancer.
Unexplained weight loss is a decrease in body weight, when you did not try to lose the weight on your own. Unintentional weight loss is loss of 10 pounds OR 5% of your normal body weight over 6 to 12 months or less without knowing the reason. Chronic digestive system problems that decrease the amount of calories and nutrients your body absorbs, including: Your health care provider may suggest changes in your diet and an exercise program depending on the cause of your weight loss. You or a family member loses more weight than is considered healthy for their age and height. You have lost more than 10 pounds OR 5% of your normal body weight over 6 to 12 months or less, and you do not know the reason. You have other symptoms along with the weight loss. The health care provider will do a physical exam and check your weight. You will be asked questions about your medical history and symptoms, including: How much weight have you lost? When did the weight loss begin? Has the weight loss occurred quickly or slowly? Do you have occasional uncontrollable hunger with palpitations , tremor, and sweating ? Do you have increased thirst or are you drinking more? Are you pleased or concerned with the weight loss?
Given that unintentional weight loss is a common condition among older adults and is associated with adverse outcomes, our objective was to review the evidence regarding risk factors, differential diagnosis, prognosis, investigation and treatment of unintentional weight loss in this population. Based on evidence from a large cohort study that involved 4010 persons aged 65 years and older from 11 cities in Europe, the most common independent factors associated with unexplained weight loss are those related to food intake. 10 In multivariate analysis, only difficulties in bringing food to the mouth and chewing were significantly associated with weight loss. A chart review of 290 medical records from many centres in the United States that included long-term care residents and home care clients found six factors to be associated with unexplained weight loss. A cross-sectional study of 68 community-dwelling older adults in the midwestern United States (with an average age of 86 years and 51 of whom were women) showed that depression (using the Geriatric Depression Scale) was independently associated with weight loss (OR 1.65, 95% CI 1.12–2.43). 12 Another prospective study (n = 309) found that psychiatric and psychological diseases are one of the primary reasons for unexplained weight loss. Another prospective trial randomized 29 dieticians to the provision of usual nutritional care or a new medical nutritional therapy protocol for prevention and treatment of unexplained weight loss among long-term care residents. One study also looked at the use of dronabinol for unexplained weight loss. Medications that are not clearly required and that may be contributing to the weight loss should be discontinued or appropriate alternatives considered. What is the prognosis for those with unintentional weight loss? Although treatment remains a challenge, clinicians should attempt to identify and address factors that may be contributing to the weight loss. A comprehensive history and physical examination has the greatest potential for eliciting the cause(s) of weight loss.
PCM in cancer results from multiple factors most often associated with anorexia, cachexia, and the early satiety sensation frequently experienced by individuals with cancer. Anorexia, the loss of appetite or desire to eat, is typically present in 15% to 25% of all cancer patients at diagnosis and may also occur as a side effect of treatments. Cachexia is estimated to be the immediate cause of death in 20% to 40% of cancer patients; it can develop in individuals who appear to be eating adequate calories and protein but have primary cachexia whereby tumor-related factors prevent maintenance of fat and muscle. The etiology of cancer cachexia is not entirely understood. Anorexia, cachexia, and nutrition. American Cancer Society: Nutrition for the Person with Cancer: A Guide for Patients and Families. Vigano A, Watanabe S, Bruera E: Anorexia and cachexia in advanced cancer patients. Shils ME: Nutrition and diet in cancer management. Ottery FD: Cancer cachexia: prevention, early diagnosis, and management. Zeman FJ: Nutrition and cancer. Also known as cachexia, this condition is one of advanced protein-calorie malnutrition and is characterized by involuntary weight loss, muscle wasting, and decreased quality of life.[ 1 , 2 ] Tumor-induced weight loss occurs frequently in patients with solid tumors of the lung, pancreas, and upper gastrointestinal tract and less often in patients with breast cancer or lower gastrointestinal cancer. Although an individual’s nutritional status may be compromised initially by the diagnosis of cancer, thorough nutritional screening procedures and the timely implementation of nutritional therapies may markedly improve the patient’s outcome. Several approaches to the treatment of cancer cachexia have been reported, and a variety of agents have been studied for their effects on appetite and weight. Table 1 lists several medications that have been proposed to treat the symptoms of cancer cachexia.[ 13 ] However, the management of cachexia remains a complex challenge, and integrated multimodal treatment targeting the different factors involved has been proposed.
Signs and Symptoms of Cancer. How does cancer cause signs and symptoms? The signs and symptoms will depend on where the cancer is, how big it is, and how much it affects the organs or tissues. If a cancer has spread (metastasized), signs or symptoms may appear in different parts of the body. This pressure causes some of the signs and symptoms of cancer. Cancer can also cause the immune system to react in ways that produce these signs and symptoms. If cancer is not the cause, a doctor can help figure out what the cause is and treat it, if needed. What are some general signs and symptoms of cancer? You should know some of the general signs and symptoms of cancer. Along with the general symptoms, you should watch for certain other common signs and symptoms that could suggest cancer. Sores on the penis or vagina may either be signs of infection or an early cancer, and should be seen by a health professional. The signs and symptoms listed above are the more common ones seen with cancer, but there are many others that are not listed here.
Understanding unexpected weight loss. What are some possible causes of weight loss, what questions might your doctor ask, and what can you expect as you and your doctor seek to determine the cause? What Is Unexplained Weight Loss? Weight loss may occur because you are eating less, or because your body is using nutrients differently due to a change in your metabolism or the growth of a tumor. If you are losing weight without trying it is important to make an appointment to see your doctor, even if you think there is an explanation for your weight loss. Diagnosing Weight Loss That Isn’t Intentional. If you have unintentional weight loss, your doctor will first take a careful history and do a physical exam. How fast have you been losing weight? Have you ever had weight loss like this before? How upsetting is the weight loss to you? Causes of Unexplained Weight Loss. There are many reasons for unexplained weight loss, some serious, and some more of a nuisance. Importance of Unintentional Weight Loss. Unintentional weight loss in older adults . Weight Loss – Unintentional.
What are the symptoms of cancer? Topics Cancer Cancer Symptoms What are the symptoms of cancer? You should know some of the general signs and symptoms of cancer. But remember, having any of these does not mean that you have cancer - many other things cause these signs and symptoms, too. An unexplained weight loss of 10 pounds or more may be the first sign of cancer. Pain: Pain may be an early symptom with some cancers like bone cancers or testicular cancer. Back pain can be a symptom of cancer of the colon, rectum, or ovary. Skin changes: Along with cancers of the skin, some other cancers can cause skin symptoms or signs that can be seen. These signs and symptoms are the ones more commonly seen with cancer, but there are many others that are less common and are not listed here.
Cancer can be associated with involuntary weight loss, which according to Dixon, as a sign of malnutrition, is a "huge red flag." Moreover, in some cancers (eg, upper gastrointestinal tract cancers and lung cancer), unintentional weight loss may have begun before the diagnosis, so the patient is starting treatment in a state of nutritional deficiency.  Even overweight or obese patients with some types of cancer are at risk for the negative effects of malnutrition and unintentional weight loss. The flip side, says Dixon, is the phenomenon of weight gain in some cancers, particularly breast and prostate cancer, and in some patients with colon cancer. Some patients might pay less attention to a healthy diet after a cancer diagnosis, and body weight begins to creep up. Postdiagnosis weight gain of this type should be avoided, cautions Dixon, because it is associated with increased risk for cancer recurrence and mortality. For patients prone to gaining weight after a cancer diagnosis, Dixon advocates a healthy diet of vegetables, fruits, whole grains, and low-calorie foods; aerobic activity, such as walking; and other exercise, such as training with elastic resistance bands. The new cancer survivorship guidelines from the American Cancer Society even say that if obese or overweight cancer patients are on a healthy diet and exercising, losing a little weight intentionally is fine, even during treatment." 
Unexplained weight loss can be a symptom of many conditions - cancer included. Weight Loss and Cancer. Unintentional weight loss can be a symptom of cancer , though vague and non-specific. When To See Your Doctor About Weight Loss. Generally, you should see your doctor if you have lost 5 percent of your body weight within six months or less and have done so without modifying your diet or exercising. Your doctor may ask you several questions to help identify why you are losing weight. Your doctor will want to know the basics like when you first started to lose weight and how much you have lost. Remember, Weight Loss Doesn't Mean You Have Cancer. You may also get a better understanding of what your symptoms, like weight loss , may mean by using the About.com Symptom Checker , an interactive health education tool.
Because there are many potential causes of unintentional weight loss, treatment is solely tailored to target the problem that causes this condition. The workout may require light to moderate weight training to prevent the further loss of muscle tissue and to restore those that have been lost. One conventional and often physician-prescribed pharmaceutical option for weight gain is appetite stimulants. Weight loss due to reduced nutrient intake and anorexia is one of the effects of cancer. Cancer cachexia, which is a wasting syndrome, causes more than weight loss as it can lead to permanent damage of the tissues and organs in the body often leading to death. Cancer cachexia is treated with pharmaceuticals to boost appetite and reverse or, if not, at least stop the degeneration of organs and tissues. This doctor will perform a thorough and complete checkup on the patient to ascertain nothing is imbalanced in his digestive and/or endocrine system. In order to help a person regain his healthy appetite, the acupuncturist will focus his treatment on the spleen and stomach meridians to help rebalance the patient’s energy or chi energy and help him get back his natural appetite. Acupuncture is one of many alternative therapies that provide effective and totally safe strategies that focus on nutritional enhancement of the body and hormonal balance to boost appetite and regain weight. Some therapies integrate the use of high-quality foods and proteins like seeds and nuts that are loaded with calories. These are foods that any naturopathic doctor will highly recommend to his thin and emaciated patient wanting to regain weight. A patient who experiences some health improvements through acupuncture or other natural therapies, the inclusion of strength training and training exercise will help quicken the process of the patient’s weight gain.
Weight Gain and Lung Cancer. Posted in: Coping with Cancer , Health and Wellness. Q: I have a client with stage 4 lung cancer, who wants to gain some weight back. A: Unintentional weight loss is a problem for many cancer patients, and having trouble with maintaining a healthy weight can be frustrating and challenging. Approach your client to see if some of these snacks would work with his schedule, and be palatable to him: Soups are often easy to tolerate, and can make great meals and snacks. Olive and canola oil can be added to yogurt frappes or smoothies as a great calorie boost.
To establish the incidence and causes of unintentional weight loss and to compare prognoses. Determining the course of weight loss in patients with diagnosed and undiagnosed causes. The cause of weight loss was established in 132 (84%) patients and remained unclear in 26 (16%). The prognosis for unknown causes of weight loss was the same as for non-malignant causes. The cause of weight loss was diagnosed in the majority of patients, i.e. In most of the patients, the dominating cause of weight loss was a non-malignant disease (n = 94, 60% of 158). Causes of weight loss in 158 patients. The major cause of weight loss in both the non-malignant and malignant groups was a gastrointestinal disorder (n = 50, 38% of 132), with more prevalence in the non-malignant group (n = 30, 60%) than in the malignant group (n = 20, 40%). Of the 132 patients for whom the cause of weight loss could be established, 50 died: seven (4%) in hospital and 43 (27%) during follow-up ( Table 2 ). Causes of weight loss and death of the patients during follow-up. The 43 patients who died during follow-up were divided into two groups: those for whom the cause of weight loss could be established (n = 41, 31%), and those for whom it remained unknown (n = 2, 8%) ( Table 2 ). The cause of death of the two patients (one 86-year-old, and one 90) for whom the cause of weight loss could not be established was unknown ( Table 2 ). Eleven (21%) of the 52 patients with a weight loss of 5–10% died, and 39 (37%) of the 106 patients with a weight loss of > 10% died.
Cancer and Unintentional Weight Loss. 4,613,728 conversations around the web about Cancer to help you make a decision. Treato found 140 discussions about Unintentional Weight Loss and Cancer on the web. 13.3% of the posts that mention Unintentional Weight Loss also mention Cancer (140 posts) Tamoxifen vs. Medical Marijuana Tamoxifen vs. Treato does not review third-party posts for accuracy of any kind, including for medical diagnosis or treatments, or events in general. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice. Treato does not provide medical advice, diagnoses or treatment. Treato is not responsible for promotions validity, application of the promotion code varies among the different Telehealth sites (for example during registration flow). Treato is not responsible for content on external web sites.
Researchers observe harmful weight loss in patients taking a drug commonly prescribed for dementia. Researchers from the University of California-San Francisco (UCSF) are finding that commonly prescribed dementia medications can lead to dangerous weight loss in patients . Often, weight loss presents a significant problem for patients suffering with dementia, increasing their risk of succumbing to the disease. To dive further into the risks, Sheffrin and a team of researchers examined Veteran Affairs (VA) data collected from dementia patients age 65 and older during 2007 and 2010 — patients were both diagnosed and being treated either with cholinesterase inhibitors or other new medications. From this VA data, researchers matched 1,188 patients on cholinesterase inhibitors with a control group of 2,189 patients on other types of dementia medication. Overall, researchers found that 29.3 percent of patients displayed significant weight loss while on inhibitors, as opposed to 22.8 percent who were not taking the drug. This evidence led researchers to conclude that cholinesterase inhibitors presented an increased risk of weight loss to dementia patients in comparison to other drugs. For example, they'd like to examine whether or not a certain subgroup of dementia patients taking inhibitors face a higher risk of this unintentional weight loss. "Clinicians should take into account the risk of weight loss when weighing the risks and benefits of prescribing cholinesterase inhibitors in patients with dementia," the authors write.
Clinical Study of BYM 338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or the Pancreas. Home » Citations » Clinical Study of BYM 338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or the Pancreas. A safety & efficacy clinical study of the investigational medicinal product BYM 338 for the treatment of unintentional weight loss in patients with cancer of the lung or the pancreas. A Multi-center Study to Assess the Effects of BYM 338 on Skeletal Muscle in Sarcopenic Adults. The purpose of this Proof of Concept study is to determine the effects of BYM 338 on skeletal muscle volume, mass, and strength and patient function (gait speed) in non-demented elderly adu. Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. More From Bio Portfolio on "Clinical Study of BYM 338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or the Pancreas" The information provided by Bio Portfolio.com is not a substitute for professional medical advice, diagnosis or treatment. The Bio Portfolio site is sponsored Bio Portfolio Limited with offices at Stafford House, 10 Prince of Wales Road, Dorchester, DT 1 1 PW, England.
Risk factors: Weight loss is one of the most common symptoms of cancer and a common side effect of many cancer treatments. Cancer, then, is a risk factor for weight loss. This leads to a loss of fat and muscle, a wasting syndrome known as cachexia, which accounts for the emaciated look of some cancer patients. Weight loss or less than optimal weight can diminish the effectiveness of treatment. Unintentional rapid weight loss is a common symptom of cancer. The cause of such weight loss will be identified by analysis of other symptoms and test results. Screening and diagnosis: Because weight loss leads to nutrition problems such as malnutrition or anorexia, diagnosing weight loss in cancer patients is done through nutrition screening and assessment. Treatment and therapy: Preventing weight loss or encouraging weight gain is a major part of cancer treatment. Before actual treatment of the cancer, doctors treat any complications that may arise from weight loss. Drug therapy and medical nutrition therapy help patients gain or maintain a healthful weight, along with stores of energy, to better battle the cancer.
However, occasionally, the first symptom to develop in some serious diseases is weight loss. Some people may see a doctor to say that they have lost weight and don't know why. However, occasionally, weight loss is the first symptom noticed. So, weight loss is sometimes the first thing reported to a doctor. Weight loss may develop due to not eating much. It may be friends or family who actually notice that the person has lost weight. Family and friends may show concern about weight loss and not be aware that the person has an alcohol problem. But, occasionally, the first symptom that is noticed with infections such as tuberculosis or HIV is weight loss. However, weight loss may be the first symptom noticed. Again, it is sometimes friends or family who may first notice that a person is not right and has lost weight and it then turns out to be the early stages of dementia. See individual leaflets on the various diseases that can cause weight loss.
Weight loss is common among people with cancer and is often the first noticeable sign of the disease. As many as 40% of people with cancer report unexplained weight loss at the time of diagnosis, and up to 80% of people with advanced cancer experience weight loss and cachexia, or wasting, which is the combination of weight loss and muscle mass loss. Weight loss and muscle wasting also often come with fatigue , weakness, loss of energy, and an inability to perform everyday tasks. Controlling cancer-related weight loss is important for your comfort and well-being. Consider asking your doctor about receiving food through a tube that goes directly to the stomach, which may help people with head and neck or esophageal cancers who are having difficulty chewing or difficulty swallowing . Megestrol acetate (Megace) is a progesterone hormone that can improve appetite, weight gain, and a person's sense of well-being. Steroid medications can increase appetite, improve a person's sense of well-being, and help with nausea, weakness, or pain. Other medications are being studied to help people with cancer improve their appetite and gain weight. Nutrition counseling may help people with cancer get essential nutrients, such as protein, vitamins, and minerals into their diet and maintain a healthy body weight. You can also find a dietitian through the Academy of Nutrition and Dietetics. These details can help you work with your health care team to find the best way to maintain your weight, or gain needed weight, during cancer treatment.
Unintentional Weight Loss in Older Adults. Patient information: See handout on unintentional weight loss in older adults , written by the authors of this article. Unintentional weight loss in persons older than 65 years is associated with increased morbidity and mortality. Overall, nonmalignant diseases are more common causes of unintentional weight loss in this population than malignancy. Social factors may contribute to unintentional weight loss. Appetite stimulants may increase weight but have serious adverse effects and no evidence of decreased mortality. Unintentional weight loss (i.e., more than a 5% reduction in body weight within six to 12 months) occurs in 15% to 20% of older adults and is associated with increased morbidity and mortality. 1 In this population, unintentional weight loss can lead to functional decline in activities of daily living, 2 increased in-hospital morbidity, 3 increased risk of hip fracture in women, 4 and increased overall mortality. Because unintentional weight loss is a nonspecific condition and no published guidelines exist for evaluation and management, the appropriate workup, if any, is difficult to determine. This article focuses on the evaluation, diagnosis, and potential treatments of unintentional weight loss in patients older than 65 years.
While it's more common for people to gain weight during and after treatment, some people lose weight. Managing weight changes. Managing weight gain. Visit the Breastcancer.org Eating to Lose Weight After Treatment pages in the Nutrition section for more tips. Managing weight loss. Visit the Breastcancer.org Eating to Maintain or Gain Weight After Treatment pages in the Nutrition section for more tips.
Unintentional weight loss is when you lose weight without dieting or increasing physical activity. What Causes Unintentional Weight Loss? Unintentional weight loss is often the result of an underlying chronic medical condition. What Are the Symptoms of Unintentional Weight Loss? Certain medications can cause unintentional weight loss as a side effect. How Is Unintentional Weight Loss Diagnosed? Note when the weight loss started. Also, make a note of any other symptoms you experienced around the time of the weight loss. Unintentional weight loss is a symptom of several conditions. What Are the Treatment Options for Unintentional Weight Loss? Your doctor will likely prescribe medication if a hormonal disorder is causing the unintentional weight loss. If your doctor suspects that your unintentional weight loss may be due to a more serious illness, such as cancer, you may undergo some tests to get more information.
The type of cancer you have. Your type of cancer can affect how likely it is that you will have digestive problems. As many as 1 in 4 people diagnosed with cancer have loss of appetite. This is weight loss when you are not trying to. Losing weight is often associated with loss of appetite. Your body may not be absorbing all the fat, protein and carbohydrate from the food you eat. How much weight you lose can depend on the type of cancer you have. About 6 out of 10 people (60%) with lung cancer and 8 out of 10 people (80%) with stomach cancer, pancreatic cancer or oesophageal cancer have lost a significant amount of weight by the time they are diagnosed. If you are not dieting and you lose more than 5% of your normal weight in 1 month, or 10% in 6 months, your doctor will want to find out the cause. Anorexia just means loss of appetite and is often associated with cachexia, but not always. Cachexia in advanced cancer can be very upsetting and make you feel very weak. Because your body is using up energy faster than it is getting it, you can have severe weight loss even if you are eating normally. This can all be made worse because of the side effects of cancer treatment you are having.
Lymphoma and Unintentional Weight Loss. 120,978 conversations around the web about Lymphoma to help you make a decision. Treato found 21 discussions about Unintentional Weight Loss and Lymphoma on the web. 2% of the posts that mention Unintentional Weight Loss also mention Lymphoma (21 posts) Treato does not review third-party posts for accuracy of any kind, including for medical diagnosis or treatments, or events in general. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice. Treato does not provide medical advice, diagnoses or treatment. Treato is not responsible for promotions validity, application of the promotion code varies among the different Telehealth sites (for example during registration flow). Treato is not responsible for content on external web sites.
Version: 2015. This guideline has been developed to advise on the treatment and management of bipolar disorder. Version: 2006. NICE Clinical Guidelines - National Collaborating Centre for Women’s and Children’s Health (UK). NICE Clinical Guidelines - National Collaborating Centre for Nursing and Supportive Care (UK). Key areas in the investigation and management of these conditions are covered in this guideline. Version: 2010. Nutritional Supplementation for Patients with Cancer: A Review of the Clinical Effectiveness and Guidelines [Internet] This guideline has been developed to advise on the treatment and management of psychosis and schizophrenia in adults. Version: 2014.