TOPAMAX® can increase the level of acid in your blood (metabolic acidosis). If left untreated, metabolic acidosis can cause brittle or soft bones (osteoporosis, osteomalacia, osteopenia), kidney stones, can slow the rate of growth in children, and may possibly harm your baby if you are pregnant. Your healthcare provider should do a blood test to measure the level of acid in your blood before and during your treatment with TOPAMAX®. If you are pregnant, you should talk to your healthcare provider about whether you have metabolic acidosis. If you take TOPAMAX® during pregnancy, your baby has a higher risk for birth defects called cleft lip and cleft palate. Tell your healthcare provider right away if you become pregnant while taking TOPAMAX®. You and your healthcare provider should decide if you will continue to take TOPAMAX® while you are pregnant. If you become pregnant while taking TOPAMAX®, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry. TOPAMAX® can slow your thinking and motor skills and may affect vision. These are not all the possible side effects of TOPAMAX®.
Each day you have a migraine headache, put that in your diary. Where you were and what you were doing when the migraine started. Each day you have your period, not just the first day (This can allow you and your doctor to see if your headaches occur at the same or similar time as your period.) Talk with your doctor about what sets off your headaches to help find the right treatment for you. The two forms seen most often are migraine with aura and migraine without aura. You can't tell the difference between a migraine and a tension-type headache by how often they occur. If you think you get migraine headaches, talk with your doctor. Your doctor may be able to diagnose migraine just from the information you provide. Work with your doctor to decide on the best tests for you. How the menstrual cycle and migraine are linked is still unclear. Talk with your doctor if you think you have menstrual migraine. Because not everyone responds the same way to migraine drugs, you will need to work with your doctor to find the treatment that works best for you. Talk with your doctor if migraine is a problem while you are pregnant or if you are planning to become pregnant. Talk with your doctor if the amount of medicine you are prescribed is not helping your headaches.
According to the study author, Abouch Krymchantowski, director of the Headache Center of Rio, Department of Neurology, Universidade Federal Fluminense, in Brazil, topiramate is a much-preferred alternative to older migraine medications like beta-blockers and antidepressants, which caused patients to gain weight. A previous study sponsored by the drug’s manufacturer, from 2003, found that patients taking Topamax reduced their body weight by up to 4 percent while patients on different migraine medications gained up to 40 lbs. Timolol is another drug commonly prescribed to migraine patients. According to the journal "American Family Physician," sufficient evidence suggests that the beta-blocker can be used as a first-line defense for migraine prevention. According to "The New York Times," beta-blockers, typically used for treating high blood pressure, are helpful in reducing migraine frequency and decreasing the severity when migraines occur. For years, antidepressants like amitriptyline have been used as the first line of defense for migraine prevention and can help patients with insomnia.
The drug has a high potential for abuse. The drug has no currently accepted medical use in treatment in the United States. The drug has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse of the drug may lead to severe psychological or physical dependence. The drug has a potential for abuse less than the drugs in schedules 1 and 2. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to moderate or low physical dependence or high psychological dependence. The drug has a low potential for abuse relative to the drugs in schedule 3. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 3. The drug has a low potential for abuse relative to the drugs in schedule 4. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 4.
Her friend gave her Oxy ELITE Pro, a weight-loss supplement she said would give Samone the energy she needed to push through it. Samone wasn't worried; she assumed there was more to the story (and in fact, a Pentagon investigation couldn't find direct evidence that DMAA was responsible for those deaths). "We agreed that the soldiers had probably misused it," Samone says. It never occurred to her that the pills might be contributing to her symptoms, and she was determined to lose weight, so she kept taking them. So in early September, she called the FDA to report her suspicions. To her dismay, she found that "it's not the easiest thing to contact the agency. I need to go to the hospital.'" There, a liver specialist quizzed Samone on everything she had done and eaten. She thought he was talking about the first recall, and said she did. Then they checked the date and found that the new version had been recalled too, only days before. It was supposed to be off the market, but his patients didn't know and kept buying it, he says. She spent a week and a half in the hospital in 2013, awaiting the results of a biopsy of her liver.
The drug is approved for use in adults with a body mass index (BMI) of 30 or greater (obese), or adults with a BMI of 27 or greater (overweight) and who have at least one weight-related condition such as high blood pressure (hypertension), type 2 diabetes, or high cholesterol (dyslipidemia). According to the Centers for Disease Control and Prevention, more than one-third of adults in the United States are obese. D., director of the FDA’s Center for Drug Evaluation and Research. “The approval of this drug, used responsibly in combination with a healthy diet and lifestyle, provides a treatment option for Americans who are obese or are overweight and have at least one weight-related comorbid condition.” Belviq works by activating the serotonin 2 C receptor in the brain. The safety and efficacy of Belviq were evaluated in three randomized, placebo-controlled trials that included nearly 8,000 obese and overweight patients, with and without type 2 diabetes, treated for 52 to 104 weeks. In people with type 2 diabetes, about 38 percent of patients treated with Belviq and 16 percent treated with placebo lost at least 5 percent of their body weight. The approved labeling for Belviq recommends that the drug be discontinued in patients who fail to lose 5 percent of their body weight after 12 weeks of treatment, as these patients are unlikely to achieve clinically meaningful weight loss with continued treatment. Heart valve function was assessed by echocardiography in nearly 8,000 patients in the Belviq development program. There was no statistically significant difference in the development of FDA-defined valve abnormalities between Belviq and placebo-treated patients. Because preliminary data suggest that the number of serotonin 2 B receptors may be increased in patients with congestive heart failure, Belviq should be used with caution in patients with this condition.
Weight loss supplements– Weight loss pills are prescription drugs that are recommended to avoid serious health implications. The best weight loss supplements are available that alters the processes for regulating weight, alteration in appetite and absorption of calories. • Orlistat – This weight loss pill decreases fat absorption by stopping the enzyme pancreatic lipase activity. • Lorcaserin – is another weight loss pill that acts via suppressing the appetite receptors present in the brain. • Rimonabant- it suppresses the appetite and food consumption resulting in loss of weight. It is also preferred weight loss pills by the people. To buy weight loss products online order from reliablerxpharmacy.com and avail special offers and deals. Weight loss by physical workout and diet control is not an easy way, one can feel setbacks along the way, but one should keep trying. • Physical activity and exercise-Active living style are the best way to keep you away from diseases and increase longevity.
The Food and Drug Administration has approved four drugs for prevention of migraine: Propanolol and timolol are beta-blocker drugs. Divalproex and topiramate are anti-seizure drugs. Many other drugs are also being used or investigated for preventing migraines. Some beta-blockers, however, are also useful in reducing the frequency of migraine attacks and their severity when they occur. Propranolol (Inderal) and timolol (Blocadren) have been approved specifically for prevention of migraine. Metoprolol (Toprol), atenolol (Tenormin), and nadolol (Corgard) are also being studied for migraine prevention. Anti-seizure drugs, also called anticonvulsant drugs, are commonly used for treating epilepsy and bipolar disorder. Divalproex sodium (Depakote) and topiramate (Topamax) are the only anti-seizure drugs that are approved for migraine prevention. In 2004, the Food and Drug Administration approved topiramate for prevention of migraines in adults. Researchers are studying other types of anti-seizure drugs for migraine prevention, including levetiracetam (Keppra), gabapentin (Neurontin), and pregabalin (Lyrica). Although other tricyclic antidepressants may have fewer side effects than amitritpyline, they do not appear to be particularly effective for migraine prevention. It is being studied as a preventive approach for reducing the frequency of migraine attacks and patients' reliance on pain medications.
The First New FDA-approved Diet Medicines in 13 Years. In the first half of 2012 the FDA advisory committee recommended two new diet pills for approval. Beyond diet and exercise, clinicians were previously left with few medical, non-surgical options for the treatment of obesity. All of which explains why this is encouraging news for obese Americans yearning for new diet medicine options, and why the marketplace is buzzing about Qsymia and Belviq. Qsymia (formerly Qnexa): Combination diet pill with Topamax (topiramate) and phentermine. Long-term studies of the new diet pill, Qsymia, have shown significant weight loss as well as positive effects on quality of life and cardiac risk factors with the potential to lower cholesterol and blood pressure. In approving Qsymia, the FDA appears to have felt that the benefits from the weight loss and reduced risk factors more than offset the potential side effects, which include the chance of birth defects and cognitive problems with Topamax, and heart problems associated with the stimulant effects of phentermine. Don't wait, call today to see if the combination diet medicine, Qsymia (formerly Qnexa), is right for you. Off label use means that a medication is being prescribed for a purpose other than that for which it was approved by the FDA. The second new diet pill approved by the FDA, Belviq (lorcarserin) is sanctioned, in combination with a program that includes a healthy diet and exercise, as prescription therapy for long-term weight loss for adults who are obese or significantly overweight.
Phentermine has been studied numerous times for weight loss (in combination with diet and behavioral modification), as well as in the maintenance of weight loss. Weight loss was initially seen as a side effect and it has now been studied directly for use in weight loss and in binge-eating disorder. One mechanism that may contribute to its weight loss effects is its effect on taste. Who should consider using this drug? I believe its effects will be best when used with diet, exercise and behavior modification. Who should not use this drug? This drug should absolutely not be used with patients with pre-existing heart disease or women who are going to become pregnant, as it has been shown to slightly increase the risk of birth defects, such as cleft lip and palate. There are several other possible side effects that should be discussed with the doctor who prescribes it for you, prior to starting it.
DRUG CLASS AND MECHANISM: Topiramate is an oral drug that is used to prevent the seizures of epilepsy . Seizures are due to the abnormal activity ("firing") of nerves in the brain, and the abnormal activity spreads to smaller or larger portions of the brain. By altering the production or action of the neurotransmitters, topiramate may suppress the abnormal activity of the nerves in the brain that cause the seizures or may prevent the abnormal activity from spreading to other nerves. Other studies suggest that topiramate may suppress the nerves directly (i.e., not by altering neurotransmitters) and make them less likely to fire. The FDA approved topiramate as a tablet in 1997. Topiramate also is used in patients 2 years of age and older with seizures associated with the Lennox-Gastaut syndrome, a severe form of epilepsy which accounts for up to 10% of all cases of childhood epilepsy. Topiramate also is approved for the prevention of migraine headaches in adults.
Risk of Heart Attack, Stroke Also Drop After Weight Loss Surgery. June 15, 2011 - Weight loss surgery can reduce or eliminate migraine headaches and reduce the risk of heart attack and stroke , according to new research. Both studies were presented at the annual meeting of the American Society for Metabolic & Bariatric Surgery in Orlando. ' Bariatric surgery has been shown to reduce the risk of heart attack , stroke or death by 25% to 50% compared to other surgical patients,' says researcher John David Scott, MD, assistant professor of surgery at Greenville Hospital System University Medical Center in Greenville, S.
Food and Drug Administration today approved Qsymia (phentermine and topiramate extended-release) as an addition to a reduced-calorie diet and exercise for chronic weight management. “Qsymia, used responsibly in combination with a healthy lifestyle that includes a reduced-calorie diet and exercise, provides another treatment option for chronic weight management in Americans who are obese or are overweight and have at least one weight-related comorbid condition.” The safety and efficacy of Qsymia were evaluated in two randomized, placebo-controlled trials that included approximately 3,700 obese and overweight patients with and without significant weight-related conditions treated for one year. The recommended daily dose of Qsymia contains 7.5 milligrams of phentermine and 46 mg of topiramate extended-release. Qsymia is also available at a higher dose (15 mg phentermine and 92 mg of topiramate extended-release) for select patients. Results from the two trials show that after one year of treatment with the recommended and highest daily dose of Qsymia, patients had an average weight loss of 6.7 percent and 8.9 percent, respectively, over treatment with placebo. Approximately 62 percent and 69 percent of patients lost at least five percent of their body weight with the recommended dose and highest dose of Qsymia, respectively, compared with about 20 percent of patients treated with placebo. Patients who did not lose at least three percent of their body weight by week 12 of treatment with Qsymia were unlikely to achieve and sustain weight loss with continued treatment at this dose. If after 12 weeks on the higher dose of Qsymia, a patient does not lose at least five percent of body weight, then Qsymia should be discontinued, as these patients are unlikely to achieve clinically meaningful weight loss with continued treatment. Therefore, the use of Qsymia in patients with recent (within the last six months) or unstable heart disease or stroke is not recommended. Regular monitoring of heart rate is recommended for all patients taking Qsymia, especially when starting Qsymia or increasing the dose. The purpose of the REMS is to educate prescribers and their patients about the increased risk of birth defects associated with first trimester exposure to Qsymia, the need for pregnancy prevention, and the need to discontinue therapy if pregnancy occurs.
Zonegran or Zonisamide is one of the newer anti-epiletic drugs (AEDs). The medication has a very long half-life (measured in days, not hours) and therefore appropriate for one time daily dosing. The medication has multiple mechanisms of action, the relative importance of each to its anti-epileptic effect is not known. It is in the sulfa family of drugs and therefore should not be used by patients allergic to sulfa drugs. The medication should be discontinued in patients who develop a rash. The medication does not interfere with birth control pills. In open label trials, Zonegran® has been shown effective in reducing the number of migraines. Al., demonstrated a significant weight loss in obese patients taking zonegran at a dose of at least 400 mg per day. At 32 weeks, the average patient demonstrated a 9.4% weight loss. Patients lost weight in weeks 16 to 32 (although at a slower rate than weeks 0- 16 ) so the final weight loss is not known. In general, increasing the dose by one tablet per day has solved the problem.
Excedrin and Weight Loss. Excedrin. Thank you for sharing your experience! Excedrin Aspirin vs. Excedrin Ibuprofen vs. Excedrin Advil vs. Excedrin Acetaminophen vs. Excedrin and Headaches Weight Loss and Weight Gain Excedrin and Migraines Weight Loss and Protein Supplement Excedrin and Pain Weight Loss and Feeling Hungry Excedrin and Tylenol Weight Loss and Overweight Excedrin and Aspirin Weight Loss and Pain. Usage of the website does not substitute professional medical advice.
Topamax for Weight loss. Topiramate (Topamax) is used "off-label" as a weight loss pill. Weight loss > /=5% of baseline weight was achieved by 18% of subjects in the placebo arm vs 54, 61, and 67% of patients receiving topiramate 96, 192, and 256 mg/day, respectively. Weight loss > /=10% was achieved by 6 vs 29, 40, and 44%, respectively. How long will it take for topiramate for weight loss results? In clinical trials on weight loss and obesity topiramate was used at doses 96-250 mg per day. Mechanism of action: how Topiramate causes weight loss. The combination of phentermine and topiramate produces significant weight loss (up to 10%) in obese people over the course of one year, according to researchers at Duke University Medical Center 15 . Efficacy and safety of topiramate in obese subjects. The rationale and use of topiramate for treating neuropathic pain. The effect of topiramate on body weight and ghrelin, leptin, and neuropeptide-Y levels of prepubertal children with epilepsy. Weight loss and metabolic effects of topiramate in overweight and obese type 2 diabetic patients: randomized double-blind placebo-controlled trial. Topiramate, nutrition and weight change: a prospective study. The effect of topiramate on weight loss in patients with type 2 diabetes.
Drugs marketed specifically for migraines, such as the combination of acetaminophen, aspirin and caffeine (Excedrin Migraine), also may ease moderate migraine pain, but aren't effective alone for severe migraines. The prescription pain reliever indomethacin may help thwart a migraine headache and is available in suppository form, which may be helpful if you're nauseated. Triptans effectively relieve the pain and other symptoms that are associated with migraines. Ergotamine may cause worsened nausea and vomiting related to your migraines and other side effects, and it may also lead to medication-overuse headaches. Because migraines are often accompanied by nausea, with or without vomiting, medication for nausea is appropriate and is usually combined with other medications. Preventive medications can reduce the frequency, severity and length of migraines and may increase the effectiveness of symptom-relieving medicines used during migraine attacks. In most cases, preventive medications don't stop headaches completely, and some drugs cause serious side effects. Beta blockers, which are commonly used to treat high blood pressure and coronary artery disease, may reduce the frequency and severity of migraines. Tricyclic antidepressants may reduce the frequency of migraine headaches by affecting the level of serotonin and other brain chemicals. Some anti-seizure drugs, such as valproate sodium (Depacon) and topiramate (Topamax), seem to reduce the frequency of migraine headaches. Taking nonsteroidal anti-inflammatory drugs, especially naproxen (Naprosyn), may help prevent migraines and reduce symptoms. Headache, migraine and stroke.
Migraine. A migraine headache can cause intense throbbing or a pulsing sensation in one area of the head and is commonly accompanied by nausea, vomiting, and extreme sensitivity to light and sound. Accessed April 4, 2013. Pathophysiology, clinical manifestations and diagnosis of migraine in adults. Acute treatment of migraine in adults. Estrogen-associated migraine. Accessed April 5, 2013. Accessed April 8, 2013. Preventive treatment of migraine in adults. Accessed April 9, 2013. Headache, migraine and stroke. Management of migraine headache in children. Accessed April 10, 2013. Accessed April 26, 2013. April 25, 2013.
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Topamax (topiramate) for Migraine Prevention: "I take 25mg in the morning and 50 at night. Took 2-3 months for the fingers and toes to stop tingling but I had that in the toes any ways from nerve damage in the back. I had been non-functioning for a while and this drug was a dream. For Bulimia: "I been on this medication for almost a year and a half. Topamax (topiramate) for Migraine Prevention: "This is the worst drug I've ever taken. In the end, the medication was discontinued by my doctor and I gained 23lbs of the weight back. In the end, the medication was discontinued and I gained 23lbs of the weight back. For Migraine Prevention: "In the end I'd rather have the headache" For Bipolar Disorder: "I started noticing the weight loss end of January. Yours T (taken for 1 to 6 months) February 26, 2016. For Migraine Prevention: "I was on Topamax for over 15 yrs and am finally coming off of it. So the Dr prescribed me topamax for both. (taken for 1 to 6 months) February 13, 2016. Topamax (topiramate) for Migraine Prevention: "It lessened the frequency of my migraines. For Obesity: "I just started taking this medication today (02.08.16) for weight loss.
Can I take TOPAMAX with other prescription medications? Sometimes the dose of some of your other medicines or TOPAMAX will have to be adjusted. Tell your healthcare professional if your menstrual bleeding changes while you are taking birth control pills and TOPAMAX. The rule with TOPAMAX is to "start low and go slow." That is, your healthcare professional will adjust your medication. However, if you are within 6 hours of taking your next scheduled dose, wait until then to take your usual dose of TOPAMAX, and skip the missed dose. Before taking TOPAMAX, tell your healthcare professional if you have eye problems, especially glaucoma. Your healthcare professional will probably stop TOPAMAX and may recommend other therapy. You should talk to your doctor about the best kind of birth control to use while you are taking TOPAMAX. Tell your healthcare provider right away if you become pregnant while taking TOPAMAX. You and your healthcare provider should decide if you will continue to take TOPAMAX while you are pregnant. Pregnancy Registry: If you become pregnant while taking TOPAMAX, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry. It is not known if the TOPAMAX that passes into breast milk can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you take TOPAMAX. Your healthcare professional will tell you how to slowly stop taking TOPAMAX.
Medicines to stop a migraine . These may be over-the-counter or prescription medicines. Medicines to prevent migraines . These drugs are often called preventive medicines. Finding the right mix of medicines for you may take some time. If your migraines are mild to moderate, you may need only an over-the-counter drug to stop the pain. Your doctor may suggest that you take a mix of medicines to stop a headache. For example, you may take acetaminophen or naproxen along with a prescription medicine, such as a triptan. Medicines to prevent a migraine.
Mary Williams wanted to lose weight and was ready to do the work. A daily dose of Qnexa - an experimental weight loss drug that combines phentermine with topiramate, a drug approved for epilepsy and migraine prevention - along with a diet and exercise helped Williams drop 38 pounds and six dress sizes in a year. "When I would visit with friends and colleagues they would say, 'Something has changed, you've lost weight.' They were so impressed," Williams said. But despite the promising results, the Food and Drug Administration rejected an application from drug maker Vivus to have Qnexa approved for the treatment of obesity, citing safety concerns. "As clinicians and clinical researchers, we'd all consent that the FDA seem to have set a very different safety bar for drugs that treat weight loss compared to drugs that treat other conditions," said Dr. Qnexa was one of three weight loss drugs nixed by the FDA in 2010. "I do get a little lazy sometimes and do want to eat some of the goodies I see before me," Williams said. "We're working diligently to resubmit the drug application," Tam said. Gadde and Tam said they think the FDA is being hard on weight loss drugs because of the number of Americans who would use them. Williams said she hopes the FDA will allow clinicians to weigh the risks and benefits of the drug for their patients. "It would be helpful for me if the FDA would pass it."
Before wading into the muddy waters of whether Topamax is effective for bipolar disorder, let’s look at one thing that everybody can agree on: Topamax causes weight loss. In terms of efficacy, TCR‘s reading of the literature is that Topamax is probably not effective as monotherapy for acute mania, but that it works pretty well as adjunctive therapy for treatment resistant bipolar disorder. While TCR often slams drugs that have no better quality of evidence than this, we have to admit that there is an impressive number of published trials, and that the results are pretty consistently positive for Topamax (1). The typical result is that Topamax add-on results in improvement in 50-60% of patients. Susan Mc Elroy and her colleagues at the University of Cinncinatti devised a study to see whether adding Topamax to the existing regimens of bipolar patients would make any difference (2). These patients were then regularly assessed with standard rating scales, and the mean duration of treatment was about 7 months; the average final dose of Topamax was 245 mg QD. The results were fairly dramatic, in that adjunctive Topamax worked great for the 63% of patients who entered the study with hypomanic, manic, or mixed symptoms, but it didn’t do much of anything for most of the patients with bipolar depression. The bottom-line from the Mc Elroy study: use Topamax as add-on for your bipolar patients when they have some manic component to their presentation; it’s unlikely to be helpful when they are depressed. A nice chart review published by Marcotte and colleagues reviewed the results of adding Topamax to the regimens of 58 treatment refractory patients, most of whom had either bipolar disorder or schizoaffective disorder, and 44 of whom were rapid cyclers (3).
Comment from: chrisca562, 25-34 Female on Treatment for 1-2 years (Patient) Published: January 16. Comment from: katydid, 45-54 on Treatment for 1-6 months (Patient) Published: June 26. Comment from: jlyons506, 45-54 on Treatment for 6 months - 1 year (Patient) Published: November 29. Comment from: HAWKEYE, 45-54 Female on Treatment for 6 months - 1 year (Patient) Published: June 07. Comment from: Joy4u2, 55-64 on Treatment for 1-2 years (Patient) Published: September 26. I was put on Topamax for depression and for weight problems last year at this time I weighed 220 I'm now at 165 I eat well and more healthy not wanting junk food any more. Comment from: 25-34 on Treatment for 1-2 years (Patient) Published: October 21. Comment from: mercury013, 25-34 on Treatment for 1-2 years (Patient) Published: March 04. I took Topamax for over a year, but not for the usual use. I eased off of it about a year sober and am soooo thankful this was around for me to take. Comment from: Alpaige, 25-34 on Treatment for 5-10 years (Patient) Published: September 21. My daughter and I both take Topamax for mood stabilization. I think this may not be the med for her at all. Comment from: papergirl, 35-44 on Treatment for 1-2 years (Patient) Published: January 06. If you can bear with the side effects for the first two months, it is so worth it.
Prescription Migraine Medications. Which migraine medications are safe to use while breastfeeding? Migraine medications overview. Migraine medications do not cure migraines. Instead, migraine drugs treat the symptoms using one of two approaches. Some migraine drugs relieve symptoms. Other migraine drugs are used to prevent a migraine attack. While this type of treatment provides relief, it doesn't target the physiological processes that underlie a migraine attack. Migraine symptoms occur, in part, because of the dilation of blood vessels in the brain. But newer migraine drugs known as triptans cause constriction of blood vessels and also bring about a general interruption in the chain of chemical events that leads to a migraine. No migraine drugs specifically prevent migraines.
Migraine Preventive Medication Topamax for Weight Loss. An investigational weight loss pill called Qnexa combines the medications Topamax and Phentermine. Phentermine is one of the most widely-used medications for weight loss in the United States. An investigational trial has shown an average weight loss of 22 pounds in one year for patients taking Qnexa and lower blood pressure, cholesterol and blood glucose levels. In fact, the Food and Drug Administration (FDA) recently rejected Qnexa’s application for approval as a weight loss medication because of these risks, particularly the heart risks and birth defects. They don’t believe the weight loss would necessarily sustain itself if the patients stop taking Qnexa.
The Food and Drug Administration (FDA) recently approved Qsymia (phentermine and topiramate extended release) and Belviq (lorcaserin hydrochloride) weight loss pills for management of obesity. How do Qsymia and Belviq work? Both Qsymia and Belviq are approved for weight management in obese and overweight adults. With the recommended dose of 7.5 mg/46 mg, average weight loss was 6.7% over placebo. With the recommended dose of 15 mg/92 mg, average weight loss was 8.9%over placebo. Patient treated with Belviq lost an average of 3% to 3.7% of body weight. How are Qsymia and Belviq administered? With the FDA approval of Qsymia and Belviq weight loss pills, patients who are obese can potentially benefit from these two therapies. Qsymia and Belviq are available. Qsymia and Belviq Drugs for Obesity, Weight Loss | Psych Central .
On Tuesday, the Food and Drug Administration ( FDA ) approved Qsymia, the second new diet drug in a month, and the most effective of the weight-loss pills that the agency has considered in recent years. (MORE: A Brief History of Diet Pills and the FDA ) The drug is approved for obese adults with a body mass index, or BMI, of 30 or higher. Some doctors have already been prescribing the two drugs together for weight loss. In clinical trials, overweight and obese patients taking Qsymia for a year lost differing amounts of weight: on average, patients taking a middle dose of the drug lost 8.4% of their body weight; on a higher dose, patients lost 10.6%. Most of the weight came off in the first three months, so doctors should monitor patients at that point to see if the drug is working. The FDA notes that people who don’t lose at least 3% of their body weight by three months are unlikely to go on to lose any significant weight, so they should either be counseled to discontinue the drug or to try a higher dose (Qsymia will be available in two doses). If patients still don’t lose at least 5% of their weight after three additional months on the higher dose, they should quit taking Qsymia. The drug is designed to be used in conjunction with traditional weight-management strategies like diet and exercise. Doctors stress that because of the potential risks of the drug, dieters should not use the drug for cosmetic weight loss. It will also be available in specialized pharmacies that register for the right to sell the drug, where pharmacists have been educated about Qsymia’s risks and can pass that information along to patients and doctors. Safety concerns led the FDA to reject Qsymia’s first bid for approval in 2010, but the agency and Vivus have now put in place strategies to reduce risk: for example, women of child-bearing age who want to take Qsymia must test negative for pregnancy before starting the drug and are expected to use contraception and take a pregnancy test once a month while on the drug. People with recent or unstable heart disease or stroke are not recommended to take the drug because of the potential heart risks. Vivus has also agreed to continue monitoring Qsymia users for side effects after the drug reaches market; in particular, it will conduct a long-term cardiovascular outcomes trial to assess the effect of Qsymia on major events like heart attack and stroke. The FDA’s approval of Qsymia, after such a long diet-drug drought and despite the potential safety problems that plague weight-loss pills, marks a willingness to make new solutions available.
Obesity pill Belviq: FDA approves first long-term prescription weight loss drug in 13 years. The Food and Drug Administration has approved the first new prescription drug for long-term weight loss into the U. Long wait: The anti-obesity pill Belviq is the first new prescription drug approved by the Food and Drug Administration in over a decade. Obesity rates nearing 35 per cent of the adult population, many doctors have called on the FDA to approve new weight loss treatments. The cocktail of phentermine and fenfluramine was a popular weight loss combination prescribed by doctors, though it was never approved by FDA. Obesity rates are near 35 per cent of the adult population stressing doctors to encourage the FDA to approve new weight loss treatments. Effects: The FDA said patients should stop taking Belviq after three months if they fail to lose 5 per cent of their body weight as positive results are then not expected. The FDA said patients should stop taking Belviq after three months if they fail to lose 5 percent of their body weight. Patients are unlikely to see any significant weight loss by staying with the drug. Side effects with the drug include depression, migraine and memory lapses.
The treatment for obesity is weight loss, and there are a number of ways to achieve that, including: For adults, particularly those using diet and lifestyle modifications to lose weight, the following are generally considered realistic goals: Obesity and Lifestyle Modifications. Overeating is a major contributor to obesity, and some of the most common reasons for overeating include: Lifestyle modifications that can help to address these reasons and help with weight loss include: Only a few prescription drugs are approved by the Food and Drug Administration (FDA) for the long-term treatment of obesity. Xenical is approved for use in adolescents and adults; the other three drugs are approved for use in adults only. The average amount of weight lost as a consequence of using one of these drugs ranges from 3 to 9 percent of body weight. This limits the amount of food you can eat and reduces the amount of nutrients absorbed into the body. The pouch limits how much you can eat at one time, and the band can be tightened to further reduce the size of the upper stomach.
One of the first things my Neurologist said to me about Topamax was: But still I remained positive that I was only going to suffer supermodel anorexia and none of the other possible reactions. “And this drug can interfere with the contraceptive pill, so you don’t want to get pregnant!” My Neurologist also assured me that most of the side effects would wear off and the scary ones, like going blind (I’m exaggerating for dramatic effect), would be apparent very quickly. I ran to Mum and, between lapping up water like a dog from the two jugs of water I was holding, said: He explained it actually takes some time for Kidney stones to develop, and as I’d only been on the drugs for 2 weeks it was unlikely. By now you might also have guessed the second bizarre side effect I was suffering. In the end it turned out Dad was right, I was not dying of Kidney stones. But the thirst was to such an extent that I could do nothing else all day but lie in bed and drink. Was I really going to be the first person to die from water explosion? Incidentally, I looked again at the side effects of Topamax and sure enough “Increased thirst and drinking abnormally large amounts of fluid” was listed. I do realize that of all the listed side effects, I was pretty lucky.
FDA approves obesity pill Belviq for obese, overweight people with weight-related health problems. The Food and Drug Administration approved the first prescription diet drug in a decade. The FDA announced Wednesday that the drug is approved for adults with a body mass index (BMI) of 30 or over - which indicates obesity - or with a BMI of 27 or greater (overweight) who have at least one weight-related health problem such as high blood pressure, Type 2 diabetes or high cholesterol. "The approval of this drug, used responsibly in combination with a healthy diet and lifestyle, provides a treatment option for Americans who are obese or are overweight and have at least one weight-related comorbid condition." The FDA cited three studies of nearly 8,000 overweight and obese patients - with or without Type 2 diabetes - who were treated from 52 weeks to 104 weeks with the drug or a placebo, along with exercise and diet counseling. The studies found about 47 percent of patients without Type 2 diabetes lost at least 5 percent of their body weight compared with about 23 percent of patients treated with placebo. The drug's label will recommend that people stop taking the pill if they don't lose 5 percent of their body weight after 12 weeks of treatment, as those patients are unlikely to achieve meaningful weight loss even with continuing treatment. The drug may also cause "disturbances in attention or memory," the FDA said. Belviq should be used with caution in people who have congestive heart failure, according to the FDA, but studies found no significant difference in heart valve problems between people taking Belviq and those taking a placebo. The pill was initially rejected by the FDA in 2010 , which called any weight loss the drug produces in overweight people who don't have diabetes "marginal." FDA scientists also raised concerns about health issues such as tumors that developed in laboratory animals given the drug.
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The New Silver Bullet for Weight Loss. Qnexa is a new, potent, effective and safe weight-loss drug that will help in the fight against obesity; it is poised to become the first FDA-approved weight-loss pill in 13 years. Qnexa is a combination pill of two medicines already on the market: phentermine and extended-release topiramate. It is now estimated that 2 of every 3 people are overweight, and about 30% of the population is obese. The studies that looked at Qnexa showed 9.8-14.7% weight loss, depending on the dose and the amount that you are overweight. At the time, we were using both phentermine and topiramate for weight-loss – but individually. Their side effects are quite different so that some patients did better on one drug and some did better on the other. For some, the phentermine’s effect is incomplete and adding topiramate has really helped. For most, adding the second drug boosts the appetite-suppressant effect and there is less hunger.
They are more than a headache and can affect your everyday life. There are two categories of drugs used to treat migraines: acute treatment, for pain and other symptoms during a migraine headache, and preventive treatment, to reduce the frequency and severity of headaches. These drugs are taken at the onset of migraine symptoms or auras to relieve a headache or reduce its severity. Aside from acetaminophen, an analgesic that only relieves pain, these drugs are nonsteroidal anti-inflammatory drugs (NSAIDs), which relieve pain and reduce inflammation: These drugs are taken on a regular basis, usually daily, and may be prescribed alone or in combination with other drugs. These drugs are commonly used for other conditions and are also effective for migraines. Commonly prescribed for high blood pressure, beta-blockers decrease the effects of stress hormones on your heart and blood vessels, and can help reduce both frequency and intensity of migraines:
Topamax® (topiramate) is one of the more versatile AEDs. Like all other AEDs studied in head to head trials, there is no AED which is more effective than any other AED when used as initial therapy for the correct seizure type. Topamax lacks many of the more serious side effects seen with the older AEDs. Other side effects include a change in taste, particularly with carbonated drinks, tingling in the extremities, and at times interference with mental function. Loftus has participated in multiple double-blind placebo controlled studies with Topamax and has lot of experience in its use for indications other than epilepsy. Among the most common uses of Topamax is the prevention of migraines . The medication works as well for prevention of migraines as other first class agents meaning it works well for 50% of the patients who take the medication. For those patients that are not sulfa allergic, it is common to use Zonegran® or Zonisamide before topiramate as it has fewer side effects and similar weight loss. Some patients lose weight, as high as 15-20% of their body weight in his practice, and other patients do not lose any weight. The weight loss is generally painless for the patients and they tend to come to a new weight and stabilize there. Less commonly than some of the other AEDs, Topamax is used for neuropathic pain relief. In some groups of patients, diabetics for example, the potential of weight loss is desirable and may therefore be a major reason for trying this medication for the treatment of diabetic neuropathic pain. There have been some positive and some negative results for treatment of diabetic neuropathic pain with Topamax. This is partially because it is a difficult indication to treat and partially because the side effect of tingling in the extremities is sometimes confused by patients with their neuropathy which also has a tingling quality in some patients.