Are not all the possible side effects of CONTRAVE. Tell your healthcare provider right away if you become pregnant while taking CONTRAVE. Tell your healthcare provider about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider if you cannot swallow CONTRAVE tablets whole. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure, stop taking CONTRAVE, tell your healthcare provider right away, and do not take CONTRAVE again. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE. You should check your blood sugar before you start and while taking CONTRAVE.
Contrave is for use only to help you manage your weight. You should not use Contrave if you have uncontrolled high blood pressure, seizures, an eating disorder, kidney failure, if you are pregnant or breast-feeding, or if you have recently stopped using seizure medicine. Do not use Contrave if you have used an MAO inhibitor in the past 14 days. Do not use Contrave if you are pregnant. You should not use Contrave if you are allergic to bupropion or naltrexone, or if you have: To make sure Contrave is safe for you, tell your doctor if you have: You should not breast-feed while using this medicine. Do not take Contrave with a high-fat meal, or you may be more likely to have a seizure. If you have a seizure while taking Contrave, you may never be able to take it again. You also may need to use a lower dose of any narcotic medicine you have used in the past. If you have not lost at least 5% of your starting weight after 16 weeks of treatment, this medicine may not be right for you.
I’ve been on Contrave for a month and a half. The nausea and dizziness came and went here and there but the neurological side effects were too much for me. And add more to the concept. Started back 6 days ago with 2 pills a day, not the 4 I was taking. I was on Phentermine for 4 months and lost 30 lbs. In the two weeks with diet and exercise. I’ve been taking contrave for almost 5 weeks now and have lost 17 pounds, I have no side effects except for some days I’m a little tireder then others. But other then that this pill has been my wonder blue pill and I have been very pleased with the results. Prescribed contrave for me and I have been taking it for one month with no adverse side affects. I have been for five weeks now I have not experienced any side effects and I have lost 23 pounds. For me it was worth whatever side effects could be contributed to the med. Not only was I dieting and exercising before the med and not losing weight — I was continuing to gain.
The Food and Drug Administration has approved Contrave "as treatment option for chronic weight management in addition to a reduced-calorie diet and physical activity," the agency announced on Wednesday. "Drugs are not the answer to epidemic obesity, but they can be of help in select cases," David L. More than a third of Americans are obese, and while pharmaceutical companies have been racing to find a treatment with blockbuster potential, Katz suggests that prescribing an anti-obesity drug should not become the standard treatment. First, the drug is meant to be used alongside, not in place of, a reduced-calorie diet and exercise. The Renasci researchers writing in the International Journal of Obesity noted that based on trial results so far, Contrave "would not satisfy the criterion" of the FDA's European counterpart "for a clinically effective antiobesity drug." "But the potential toxicity of this drug is considerable, and the weight will likely be regained if the drug is ever stopped." What are the side effects? What are the major drugs competing with Contrave? "The argument for approving weight loss drugs is not that [they are] really very good, but rather that 'something is better than nothing,'" he said. Contrave is not a solution to the obesity epidemic, and it's certainly not the best plan of action for most people struggling with excess weight. "As the majority of patients are unlikely to achieve the high degree of weight loss that they are seeking, it is questionable how willing they will be to pay for Contrave," the Renasi scientists note in the International Journal of Obesity .
Contrave: New Weight Loss Drug Advances. The drug is Contrave, from Orexigen Therapeutics Inc. Contrave doesn't work in the belly. The drug was tested in a clinical trial that enrolled nearly 700 obese people - 90% of them women, with an average weight of 223 pounds. All study participants enrolled in an intensive weight loss program that included counseling, diet, and exercise . Two-thirds of the study participants also took Contrave. The intensive weight loss program worked well. Moreover, 11% of participants who finished the study lost more than 15% of their body weight. After 56 weeks, they lost 9.3% of their body weight - 20 to 25 pounds. And more than 29% of them lost more than 15% of their body weight.
Contrave is weight loss medication produced in the US by Orexigen—a biopharmaceutical company that specializes in producing anti-obesity medicines. Contrave is their most recent product and the US Food and Drug Administration (FDA) has approved it for prescription use, but the tablets have the potential to cause a number of worrying side effects so the medication’s prescription-only status would appear to be warranted. What is Contrave and how does it Work? It must always be used alongside a low calorie diet and regular exercise, and it is worth noting the FDA has only approved its use as a weight loss medication when it is used in this way, not as a stand-alone weight loss initiative. Contrave contains just two active ingredients, but the manufacturer’s website fails to provide the inclusion rates. Week 1: One tablet taken in the morning. Week 2: One table in the morning + one tablet in the evening. Week 3: Two tablets in the morning + one tablet in the evening. Week 4: Two tablets in the morning + two tablets in the evening. Tablets must be swallowed whole and Orixigen warns against taking Contrave with high fat meals because this may increase the likelihood of seizures. The only side effects I’ve experienced is a little lower back pain and a dry mouth. I stuck with it for 3 weeks, but the side effects were unbearable. In the US Contrave is only available via a doctor’s prescription and it seems likely that the governing bodies of other countries will apply similar restrictions. Phen375 is available to buy direct from its own official website and does not require a prescription in most countries (including the the US, Canada, Australia and the UK)
CONTRAVE was evaluated for safety in five double-blind placebo controlled trials in 4,754 overweight or obese patients (3,239 patients treated with CONTRAVE and 1,515 patients treated with placebo) for a treatment period up to 56 weeks. In CONTRAVE clinical trials, 24% of subjects receiving CONTRAVE and 12% of subjects receiving placebo discontinued treatment because of an adverse event. The most frequent adverse reactions leading to discontinuation with CONTRAVE were nausea (6.3%), headache (1.7%) and vomiting (1.1%). Adverse reactions that were reported by greater than or equal to 2% of patients, and were more frequently reported by patients treated with CONTRAVE compared to placebo, are summarized in Table 3. Table 3: Adverse Reactions Reported by Obese or Overweight Patients With an Incidence (%) of at Least 2% Among Patients Treated with CONTRAVE and More Common than with Placebo. The following additional adverse reactions were reported in less than 2% of patients treated with CONTRAVE but with an incidence at least twice that of placebo: In the one-year controlled trials of CONTRAVE, the proportion of patients reporting one or more adverse reactions related to psychiatric and sleep disorders was higher in the CONTRAVE 32/360 mg group than the placebo group (22.2% and 15.5%, respectively). These events were further categorized into sleep disorders (13.8% CONTRAVE, 8.4% placebo), depression (6.3% CONTRAVE, 5.9% placebo), and anxiety (6.1% CONTRAVE, 4.4% placebo). Patients who were 65 years or older experienced more psychiatric and sleep disorder adverse reactions in the CONTRAVE group (28.6%) compared to placebo (6.3%), although the sample size in this subgroup was small (56 CONTRAVE, 32 placebo); the majority of these events were insomnia (10.7% CONTRAVE, 3.1% placebo) and depression (7.1% CONTRAVE, 3.1% placebo). Adverse reactions involving attention, dizziness, and syncope occurred more often in individuals randomized to CONTRAVE 32/360 mg group compared to placebo (15.0% and 5.5%, respectively). The most common cognitive -related adverse reactions were attention disorders (2.5% CONTRAVE, 0.6% placebo). Adverse reactions involving dizziness and syncope were more common in patients treated with CONTRAVE (10.6%) than in placebo-treated patients (3.6%); dizziness accounted for almost all of these reported events (10.4% CONTRAVE, 3.4% placebo). Dizziness was the primary reason for discontinuation for 0.9% and 0.3% of patients in the CONTRAVE and placebo groups, respectively. Increases in serum creatinine that exceeded the upper limit of normal and were also greater than or equal to 50% higher than baseline occurred in 0.6% of subjects receiving CONTRAVE compared to 0.1% receiving placebo.
Important Safety Information for CONTRAVE (naltrexone HCl and bupropion HCl) CONTRAVE is not approved for use in the treatment of major depressive disorder or other psychiatric disorders. In patients of all ages who are started on CONTRAVE, monitor closely for worsening, and for the emergence of suicidal thoughts and behaviors. CONTRAVE is not approved for use in pediatric patients. Although CONTRAVE is not approved for smoking cessation, observe all patients for neuropsychiatric reactions. CONTRAVE is not approved for smoking cessation treatment, but serious neuropsychiatric symptoms have been reported in patients taking bupropion for smoking cessation. Observe patients for the occurrence of neuropsychiatric reactions. Discontinue treatment and do not restart CONTRAVE in patients who experience a seizure. In patients requiring intermittent opiate treatment, CONTRAVE therapy should be temporarily discontinued and lower doses of opioids may be needed. Patients should be made aware of the risks associated with precipitated withdrawal and encouraged to give an accurate account of last opioid use. Bupropion, a component of CONTRAVE, is a drug used for the treatment of depression. The risk appears to be increased in patients with bipolar disorder or who have risk factors for bipolar disorder. Prior to initiating CONTRAVE, screen patients for history of bipolar disorder and the presence of risk factors for bipolar disorder (eg, family history of bipolar disorder, suicide, or depression). Measurement of blood glucose levels prior to starting CONTRAVE and during CONTRAVE treatment is recommended in patients with type 2 diabetes. Use caution and monitor for CNS toxicity when using CONTRAVE concomitantly with dopaminergic drugs (levodopa and amantadine).
Contrave is a combination of bupropion/naltrexone and both drugs have shown positive results for weight loss and the combination seems to have a synergistic effect. And like most FDA approved drugs for weight loss, Contrave is recommended for patients who have a body mass index (BMI) of 30 or more or have a BMI between 27 and 30 with at least one obesity symptom like hypertension with a reduced calorie diet with regular exercise. Please seek advice with a weight loss medical profession before entering into a medical weight loss program involving drugs, modified diet and exercise. Diet Doc offers their patient’s unlimited access to doctors, nurses, nutritionists and weight loss coaches at no additional charge. Diet Doc Green Fat Metabolism Burner. Diet Doc Red Fat Accelerator. Shown to increase the rate of fat loss by assisting in fat breakdown within the fat cell. Diet Doc Complex Fat Burner & Appetite Suppressant. Helps prevent fat storage and control appetite.
Weight-Loss Drug Contrave Approved by FDA. Food and Drug Administration (FDA) approved naltrexone hydrochloride and bupropion hydrochloride extended-release tablets (Contrave) for chronic weight management. Contrave is an extended-release combination drug. A number of clinical trials involving Contrave have been conductedone study in people without diabetes showed that 42 percent of those taking the medication for 1 year lost at least 5 percent of their body weight, compared with 17 percent of those who took a placebo. According to the FDA, people who take Contrave should be evaluated after 12 weeks of treatment. Contrave carries as boxed warning that bupropion may increase the risk for suicidal thoughts and actions and neuropsychiatric events such as mood changes and hallucinations. The FDA cautions that other medications containing bupropion should not be taken along with Contrave. Common side effects of Contrave include the following: Following approval of the drug, the FDA announced a number of post-marketing requirements to further evaluate the safety and effectiveness of the weight-loss drug Contrave. Clinical trial to determine if Contrave interacts with other medications. Food and Drug Administration (FDA)
In patients of all ages who are started on Contrave, monitor closely for worsening, and for the emergence of suicidal thoughts and behaviors. Contrave is not approved for use in pediatric patients [see Warnings and Precautions ( 5.1 ), Use in Specific Populations ( 8.4 )]. Contrave should be taken by mouth in the morning and in the evening. Patients may develop elevated blood pressure or heart rate during Contrave treatment; the risk may be greater during the initial three months of therapy [see Warnings and Precautions ( 5. In patients with moderate or severe renal impairment, the maximum recommended daily dose for Contrave is two tablets (one tablet each morning and evening). Contrave is not recommended for use in patients with end-stage renal disease. In patients with hepatic impairment, the maximum recommended daily dose of Contrave is one tablet in the morning [see Use in Specific Population ( 8.7 ) and Clinical Pharmacology ( 12.3 )]. Contrave contains bupropion, a dopamine and norepinephrine re-uptake inhibitor that is similar to some drugs used for the treatment of depression; therefore, the following precautions pertaining to these products should be considered when treating patients with Contrave. In placebo-controlled clinical trials with Contrave for the treatment of obesity in adult patients, no suicides or suicide attempts were reported in studies up to 56 weeks duration with Contrave (equivalent to bupropion doses of 360 mg/day). Contrave should be discontinued and not restarted in patients who experience a seizure while being treated with Contrave. Caution should be used when prescribing Contrave to patients with predisposing factors that may increase the risk of seizure including: Contrave should not be given to patients with uncontrolled hypertension [see Contraindications ( 4 )].
It’s the third obesity drug in over 10 years to get FDA approval. A new diet pill Contrave got approval to be sold in the United States on Wednesday, only the third obesity treatment in more than a decade to win approval from the Food and Drug Administration. Made by Orexigen Therapeutics Inc., Contrave is a combination of the antidepressant bupropion and Orexigen's formulation of naltrexone, designed to prevent drug dependence. Contrave joins Vivus Inc.'s Qsymia and Arena Pharmaceuticals Inc.'s Belviq, both approved in 2012, in the battle to be the treatment of choice and at least one analyst expects the new entrant's sales to top that of its rivals by 2016. Government and private health insurers are reluctant to cover Belviq and Qsymia, unconvinced of their long-term efficacy and given that patients often drop out of the treatment. "For all the obesity drugs that are out there, only 30 to 40 percent of the health maintenance organizations pay for obesity coverage," said Daniel Lang, analyst on RS Investments' Value Fund, which holds a stake in all three companies. "That speaks to the relative apathy toward obesity as a serious condition." Sales to eclipse that of Belviq and Qsymia by 2016. Contrave sales are expected to be about $200 million in 2016, slightly higher than Belviq's $180 million and well ahead of Qsymia's $150 million, said Andrews, who covers all three companies. Among these are the notorious "fen-phen" combination that was pulled out in 1997 due to heart valve problems and Sanofi SA's Acomplia, taken off the market in 2008. The shares closed up 0.85 percent at $5.90 on the Nasdaq on Wednesday.
“When used as directed in combination with a healthy lifestyle that includes a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight management for people who are obese or are overweight and have at least one weight-related health condition.” The effectiveness of Contrave was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. In this trial, 42 percent of patients treated with Contrave lost at least 5 percent of their body weight compared with 17 percent of patients treated with placebo. In this trial, 36 percent of patients treated with Contrave lost at least 5 percent of their body weight compared with 18 percent of patients treated with placebo. If a patient has not lost at least 5 percent of baseline body weight, Contrave should be discontinued, as it is unlikely that the patient will achieve and sustain clinically meaningful weight loss with continued treatment. Because it contains bupropion, Contrave has a boxed warning to alert health care professionals and patients to the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. Contrave can cause seizures and must not be used in patients who have seizure disorders. Contrave should be discontinued and not restarted in patients who experience a seizure while being treated with Contrave. Contrave can also raise blood pressure and heart rate and must not be used in patients with uncontrolled high blood pressure. Blood pressure and pulse should be measured prior to starting the drug and should be monitored at regular intervals, particularly among patients with controlled high blood pressure prior to treatment. Patients undergoing an abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs should not take Contrave. A cardiovascular outcomes trial to assess the cardiovascular risk associated with Contrave use; A clinical trial to evaluate the potential for interactions between Contrave and other drugs.
Contrave Side Effects Worry Future Users Of The Just Approved Weight-Loss Drug By FDA. Contrave is a weight-loss drug that just like any other drug has side effects. Contrave Side Effects - Like almost everything, the new drug Contrave has pros and cons, good sides and shady sides. The good sides of Contrave include: it is a mixture of two drugs that have been already approved, naltrexone and bupropion. Bupropion also helps in the narcotic side and it is essentially an antidepressant. The bad sides of Contrave are that it has side effects. Due to the heart effects, the drug had a long run before it was approved.
CONTRAVE should be discontinued and not restarted in patients who experience a seizure while being treated with CONTRAVE. Caution should be used when prescribing CONTRAVE to patients with predisposing factors that may increase the risk of seizure including: Patients should be made aware of the risks associated with precipitated withdrawal and encouraged to give an accurate account of last opioid use. In a trial that enrolled individuals with diabetes, 12.0% of patients in the CONTRAVE group and 6.5% in the placebo group had a blood pressure-related adverse reaction. Prior to initiating CONTRAVE, screen patients for a history of bipolar disorder and the presence of risk factors for bipolar disorder (e.g., family history of bipolar disorder, suicide, or depression). This information and the instructions provided in the Medication Guide should be discussed with patients. Patients should be instructed to follow the dose escalation schedule and not to take more than the recommended dose of CONTRAVE. Patients should be made aware that CONTRAVE contains the same active ingredient (bupropion) found in certain antidepressants and smoking cessation products (including, but not limited to, WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, and APLENZIN) and that CONTRAVE should not be used in combination with any other medications that contain bupropion. Patients should be advised of the potential serious risks associated with the use of CONTRAVE, including suicidality, seizures, and increases in blood pressure or heart rate. Patients should be educated on the symptoms of hypersensitivity and to discontinue CONTRAVE if they have a severe allergic reaction to CONTRAVE. Patients should be told that CONTRAVE should be discontinued and not restarted if they experience a seizure while on treatment. Patients should be advised that because naltrexone, a component of CONTRAVE, can block the effects of opioids, they will not perceive any effect if they attempt to self-administer any opioid drug in small doses while on CONTRAVE. Patients should be advised to swallow CONTRAVE tablets whole so that the release rate is not altered.
Contrave. Contrave, the latest “hopeful” in a long line of diet drugs that promise to help you lose weight, appears to have some potential. But after a few weeks of using Wellbutrin, the weight loss effect wears off and you’re back to square one. Does Contrave Work? Seventy percent of the patients also took Contrave. Results of Contrave. Contrave Side Effects. The Future Of Contrave. We all know that anyone will lose weight when taking a weight loss drug in combination with an intense, state of the art diet and exercise program.
While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings and maintain communication with your healthcare provider. Tell your healthcare provider right away if you become pregnant while taking CONTRAVE. Tell your healthcare provider about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider if you cannot swallow CONTRAVE tablets whole. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure, stop taking CONTRAVE, tell your healthcare provider right away, and do not take CONTRAVE again. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE. Your healthcare provider may need to stop treating you with CONTRAVE if you get signs or symptoms of a serious liver problem. You should check your blood sugar before you start and while taking CONTRAVE. These are not all the possible side effects of CONTRAVE.
The diet drug was rejected by the U. D ., medical director of the Clinical Nutrition Center in Denver, said that this combination was chosen because both Wellbutrin and naltrexone are used often for fighting addiction, curbing cravings, and has an off-label use of helping people to lose weight. While these drugs are not meant to replace a healthy diet and exercise regimen, they help people curb their cravings, increase their metabolism and boost their energy levels while they make changes to the behaviors that led to their struggle with weight in the first place. In 2012, two new obesity drugs were approved by the FDA, Belviq and Qsymia, which were the first new obesity drugs in 13 years. However, the acceptance of these two drugs has been slow, and the makers of Contrave hope they have more success. Marketing the Benefits of Contrave. The primary side effects include mood alterations and risks for those with liver, kidney or cardiovascular disease, all which are not uncommon among diet drugs in the U. In the end, Contrave provides enough weight loss to significantly improve many obesity related diseases and in combination with a medical weight loss program it is expected to help many people gain control of their weight.
FDA approves weight-loss drug Contrave. For the third time in two years, the FDA has approved a drug to help people lose weight. The new drug, Contrave, combines two generic drugs, naltrexone and bupropion. Contrave joins Belviq (lorcaserin) which the FDA approved in June 2012 , and Qsymia, which got the green light a month later . Does Contrave work? The FDA approved Contrave based on the results of several clinical trials that included 4,500 overweight and obese men and women. In one trial of people without diabetes, 42% of those who took Contrave lost at least 5% of their body weight, compared with 17% of those who took a placebo. In a trial of people with diabetes, 36% of those taking Contrave lost at least 5% of their body weight, compared with 18 % of those taking a placebo. If Contrave does not work after 12 weeks, the FDA says its use should be stopped. Why should the combination of a drug for addiction and one for depression help with weight loss?
Other names: Naltrexone-bupropion. Taken for: Weight Loss, Weight Gain, Obesity, Overweight. Other names: Other names: Phentermine-topiramate. Taken for: Weight Loss, Obesity, Overweight. Other names: Contrave. Category A. Category B. Category D. Category N.
What are Contrave Diet Pills? Contrave is a new diet pill that contains 2 active medicines; bupropion HCl and naltrexone HCl that as a combination have been scientifically proven to help people lose weight. Both bupropion and naltrexone are FDA approved drugs and the combination was given the name Contrave by drug’s developer Orexigen Therapeutics. Clinical trials have shown that when patients take Contrave in combination with regular exercise and dieting they lost more weight than patients who were given a placebo who followed the exact same exercise program and diet. Contrave is currently not available to buy online, however there are a number of alternative weight loss pills out there. Where to Buy Contrave Diet Pills Online? If you are looking to buy Contrave online then you should consider the following alternatives: Privately insured patients with copay the cost of Contrave is $55 per month for the first two months, and then $45 a month after that. The use of Contrave should be you have any of the following apply: Do not start using Contrave until you have stopped taking your MAOI for at least 14 days. You are allergic to naltrexone HCl or bupropion HCl or any of the ingredients in CONTRAVE.
Contrave is being slated as a chronic diet pill; if you take it and lose weight you will have to continue to take it in order to maintain lost weight. Contrave is a new weight loss pill that shows promise for being able to act on the brain's pathways that control cravings and appetite. I lost 37 lbs but in the three months since i stopped taking it I have gained 10 lbs. I have been on Contrave for 9 months and have lost 45 lbs. The only side effect that I have had is constipation. Since I have been on the Contrave and lost the weight and continue to lose, I have had my blood pressure meds cut in half and have been able to quit taken my Meloxicam that I was taking for the secondary Sjögren's. I also joined the Scale Down program that was offered when starting Contrave and it has been a BIG help! The first 2 days of taking this medication I was sick as a dog and had the worst migraine. This pill by far is the best I 've ever taken for weight loss. I have been on contrave a little over a month and I am on my second bottle and have lost 17 lbs . I've been taking contrave for 7 weeks and have lost 14.1 lbs. I have been taking contrave for a week and just up'd my dose to 2:am 1:pm. I have lost 6lbs in this first week but I'm not sure the side effects are worth it.
But the majority of the ads you see on the Internet and TV are for products that are unregulated, untested and unproven. After that, if you don't also follow a healthy eating and exercise plan, the weight will come right back. Because these drugs also reduce the body's absorption of essential vitamins and nutrients, people who take Xenical are advised to take a daily multivitamin supplement . Other, more minor side effects include constipation, headache , dry mouth and insomnia (because the chemicals in these drugs also influence sleep patterns). "Herbal" doesn't necessarily mean "safe." Also, because they are considered part of the food industry and are therefore regulated differently by the FDA, there is no guarantee that they can live up to their manufacturers' claims. To find out more about diet pills and related topics, check out the links on the next page.
Contrave Side Effects: Benefits and Complications of Weight Loss Pill. How well does it work and what are the side effects? Why Would Bupropion and Naltrexone Help People Lose Weight? One of the side effects of bupropion is loss of appetite. A lot of people taking Contrave pulled out of the clinical trials. Side Effects of Contrave. So what are the problems with this weight-loss medication? Contrave should not be considered a routine weight loss pill. The complication, though, is that the Contrave may actually increase blood pressure. The side effects of Contrave are not trivial. Our conclusion is that weight loss on Contrave is modest at best and side effects make this drug problematic.
Called Contrave, the latest drug can be used by obese and overweight adults who have at least one other obesity-related condition, such as high blood pressure or Type 2 diabetes. According to the FDA, it is only effective when used in combination with a healthy lifestyle — including a nutritious low-calorie diet and exercise — and is only to be prescribed as part of an overall weight-loss plan. D., says the new medicine holds great promise for people who combine its use with regular exercise and a reduced-calorie diet. Notes Contrave was first recommended for approval by an FDA advisory panel in 2011, but the agency rejected it at the time. Gulfo argues the FDA should have approved the drug years ago, when it had all the evidence it needed that the medication is not only effective, but also safe. And that’s what it’s really all about: [the need to] get drugs that are safe and effective in the hands of the doctors.” The FDA approved Contrave for people unable to lose weight through diet and exercise alone who aren’t ready for weight-loss surgery. And the FDA has approved two other weight-loss drugs in just the past two years — Qsymia and Belviq. But it is not for everyone, and — like past diet pills — Contrave can cause risky side effects. It can also increase blood pressure, and should not be used in people with uncontrolled high blood pressure, according to the FDA. In addition, Contrave increases the risk for seizures, and should not be used by those with seizure disorders. “[But] for the right patient who’s exercising and watching their diet, it’s great.”
Trial participants who took Contrave began losing weight four weeks after starting the drug and maintained their weight loss throughout the 56 weeks of the study. Contrave works on the same biological systems that control mood and appetite, and it's the first drug to combine buproprion and naltrexone as a way to lose weight. Ken Fujioka, a study co-author and director of the Center for Weight Management, Scripps Clinic. Fujioka is also on the advisory committee for Orexigen, the company that manufactures Contrave. "It's pretty good for rapid weight loss, but when you stop it, the weight comes right back," said Niswender. "It's generic, so it's the cheapest," said Dr. Orlistat is a fat blocker, and while doctors say it's only mildly effective for weight loss, it's very safe. Contrave is one, and the others are Qnexa and Lorcascerin. "The FDA is very sensitive to issues about drugs that target systems that control mood, addiction and reward," said Niswender. "Out of the past 50 years, there have only been three medications approved, and one is already off the market," said Kushner. "A third of the population is obese, and we only have a few medications."